Using the protein alpha-helix in teaching
نویسندگان
چکیده
منابع مشابه
Protein-protein interactions affect alpha helix stability in crowded environments.
The dense, heterogeneous cellular environment is known to affect protein stability through interactions with other biomacromolecules. The effect of excluded volume due to these biomolecules, also known as crowding agents, on a protein of interest, or test protein, has long been known to increase the stability of a test protein. Recently, it has been recognized that attractive protein-crowder in...
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The inhibition of protein-protein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry of side-chain residues on one face of the alpha-helix; these residues frequently play a key role in mediating protein-protein inte...
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Helices are one of the most common and were among the earliest recognized secondary structure elements in proteins. The assignment of helices in a protein underlies the analysis of its structure and function. Though the mathematical expression for a helical curve is simple, no previous assignment programs have used a genuine helical curve as a model for helix assignment. In this paper we presen...
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The design of novel protein ligands and inhibitors of protein– protein interactions is an important goal in post-genomic proteome analyses and in drug and vaccine discovery. Unfortunately, the design of synthetic molecules that target surface-exposed regions on folded proteins is presently difficult. Moreover, typical libraries of small “druglike” compounds have so far not been a fruitful sourc...
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ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 1984
ISSN: 0021-9584,1938-1328
DOI: 10.1021/ed061p565.2